Glabrescione B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Glabrescione B (GlaB) 是一种与 Gli1 锌指结合的小分子，通过干扰 Gli1/DNA 相互作用来损害 Gli1 活性。

Glabrescione B (GlaB) is a small molecule binding to Gli1 zinc finger and impairing Gli1 activity by interfering with Gli1/DNA interaction, inhibits Hh signaling by impairing Gli1 function; inhibits the growth of Hedgehog-dependent tumor cells in vitro and in vivo, inhibits Gli1-dependent growth of cerebellum-derived normal progenitors; inhibits the growth of Gli-dependent medulloblastoma and tumor-derived stem-like cells; inhibits the growth of Gli-dependent basal cell carcinoma in vitro and in vivo.

Glabrescione B (5 μM; 24-72 hours) inhibits the growth of Gli-dependent basal cell carcinoma.Glabrescione B (1-10 μM; 24-48 hours) decreases Gli1 mRNA expression levels. Cell Proliferation Assay Cell Line:ASZ001 BCC cells Concentration:5 μM Incubation Time:24-72 hours Result:Basal cell carcinoma cell proliferation was impaired.Western Blot Analysis Cell Line:ASZ001 BCC cells Concentration:1-10 μM Incubation Time:24-48 hours Result:Gli1 mRNA expression levels was decreased.

Animal Model:Female NOD/SCID mice (ASZ001 BCC allografts) Dosage:100 μmol/kg Administration:I.p.; every second day for 18 days Result:A significant reduction of tumor growth as well as Gli1 mRNA levels was observed.

GlaB

Wnt/Notch/Hedgehog

Gli

Gli

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65893-94-9

450.531

C27H30O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (221.97 mM)

——

3-[3,4-bis(3-methylbut-2-enoxy)phenyl]-5,7-dimethoxychromen-4-one

(-20℃)

With Ice Pack

≥ 2 years